How understudied populations leverage our understanding of Alzheimer’s disease genetics

Advances in genetics: widening our understanding of prostate cancer

Prostate cancer is a leading cause of cancer-related death in Western men. Our understanding of the genetic alterations associated with disease predisposition, development, progression, and therapy response is rapidly improving, at least in part, owing to the development of next-generation sequencing technologies. Large advances have been made in our understanding of the genetics of prostate ca...

Understanding Crohn's disease through genetics

Crohn’s disease (CD) is a chronic inflammatory bowel disease (IBD) with an eitologically complex pathology. Current evidence implicates dysregulation of the immune response to intestinal microflora and a parallel defect in maintenance of the epithelial barrier. The host genetic makeup is a key variable that underlies risk of disease, as highlighted by genomewide association studies (GWAS). This...

The Genetics of How Dogs Became Our Social Allies

The role of genetics in alzheimer’s disease

Alzheimer's disease is a progressive neurological disorder that causes the brain to shrink (atrophy) and brain cells die. Alzheimer's disease is the most common cause of dementia and causes a decrease in thinking skills and social behaviors. Alzheimer's disease is more common in people over 65 years old. The risk of developing Alzheimer's disease and other types of dementia increases with age,...

How neuropsychology informs our understanding of developmental disorders.

This review includes 1) an explanation of what neuropsychology is, 2) a brief history of how developmental cognitive neuroscience emerged from earlier neuropsychological approaches to understanding atypical development, 3) three recent examples that illustrate the benefits of this approach, 4) issues and challenges this approach must face, and 5) a forecast for the future of this approach.